El Joe, a genius, singer and composer, who with his tropical music and singular voice brought together overflowing crowds. In a hotel room in New York begins the journey of an artist who finds alienation in his multiple tours. Joe runs away with the love of his life: the crack pipe; the permanent and the established; that and his music, the sounds and Umo, his manager, his servant, his friend. Another slamming door, Joe sick and tired, locks himself in a fleabag hotel, set up to record the album of his life. He and his musicians would go together on a psychedelic trip. Joe closes the curtains of the hotel room in Bogotá. There is women stuff all over the place. Searching, jealous and paranoid; he is convinced that Mary, his Muse of inspiration, is being unfaithful. Cuero Duro finds the man who sabotaged every single thing he loved, to lock himself back in a random room, in a random city.